Product Description
CHO-K1 (Chinese Hamster Ovary, K1 subclone) is a robust, widely used mammalian cell line derived from the ovary of the Chinese hamster (Cricetulus griseus). It is the preferred workhorse for biologics development and manufacturing, with over 70% of FDA-approved therapeutic proteins produced in CHO cells. ORF Biologics provides authenticated, high-viability CHO-K1 cells with proven performance in protein expression, synthetic biology, and basic research applications.
It is synthesized as a precursor, then cleaved to form a mature A chain, which dimerizes to become active. Its activity is tightly regulated by decoy receptors, secreted inhibitors (e.g., Follistatin), and alternative subunit incorporation. In research, recombinant Activin A is widely used to support stem cell proliferation and drive differentiation into endodermal and pancreatic lineages.
PRODUCT APPLICATION
- Biopharmaceutical Production: Ideal host for monoclonal antibodies, Fc-fusion proteins, growth factors, enzymes, and cytokines
- Synthetic Biology: Compatible with stable expression systems and high-throughput screening
- Research Tools: Suitable for functional studies of signaling pathways, toxicity testing, and reporter assays
PRODUCT SPECIFICATIONS
| Format | Cryopreserved, ≥5 x 10⁵ viable cells per vial |
| Shipping | Dry ice |
| Storage | Vapor phase liquid nitrogen (-150°C or colder) |
| Viability Post-Thaw | ≥90% |
| QC Testing | Mycoplasma: Negative Bacterial & fungal contamination: Negative Cell identity: STR-verified |
