Product Description
Platelet-Derived Growth Factor-BB (PDGF-BB) is a biologically active homodimeric isoform of the PDGF family, playing a critical role in cell proliferation, migration, and tissue repair. It functions by binding to PDGF receptors (PDGFR-α and PDGFR-β), triggering receptor dimerization and activation of downstream signaling pathways such as MAPK, PI3K/AKT, and JAK/STAT. These pathways regulate the behavior of mesenchymal cells, smooth muscle cells, fibroblasts, and pericytes, contributing to processes like angiogenesis, wound healing, and tissue remodeling.
PDGF-BB is highly expressed during embryogenesis and in response to tissue damage, where it supports vascular stabilization, extracellular matrix formation, and recruitment of supportive cells to nascent blood vessels. In adult tissues, it continues to influence repair and fibrosis pathways. Recombinant PDGF-BB is widely used in vitro to promote proliferation and migration of mesenchymal and vascular cells, stimulate tissue regeneration, and model fibrotic and oncogenic signaling. It is a powerful tool in regenerative medicine, cancer biology, and biomaterial-based therapeutic development.
Applications
- Mesenchymal cell proliferation and migration studies
- Fibroblast activation and extracellular matrix production
- Angiogenesis and vascular stabilization research
- Wound healing and tissue regeneration models
- Smooth muscle cell biology and vascular remodeling studies
- Pericyte recruitment and vessel maturation in co-culture systems
- Fibrosis modeling in liver, lung, kidney, and cardiac tissues
- Cancer research, including tumor stroma interactions and PDGF signaling
- Tissue engineering and biomaterial integration studies
Product Specifications
| Storage | -20°C |
| Storage Information | Avoid freeze/thaw cycles |
| Species | Human |
| Amino Acid Sequence | SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT |
| Molecular Weight | 12.3 kDa (Expected) |
| Class | Recombinant |
| Purity | > 95% by SDS-PAGE gel |
| Endotoxin Concentration | < 1 EU/µg |
| Biologically Active | Yes |
| Biological Activity | The biological activity is confirmed by the stimulation of Balb/c 3T3 cells. |
| Form | Lyophilized |
| Shipping Conditions | Ambient |
| Reconstitution | Reconstitute with PBS + 0.1% BSA |
