Product Description
Activin A is a key member of the TGF-β superfamily, essential for proper development and produced by various cell types. It functions as a bioactive disulfide-linked homodimer, binding to Activin receptors (RIA, RIB, RIIA, RIIB) to activate SMAD signaling pathways. This signaling regulates processes such as stem cell maintenance, differentiation, B-cell proliferation, wound healing, metabolism, and gonadal development.
It is synthesized as a precursor, then cleaved to form a mature A chain, which dimerizes to become active. Its activity is tightly regulated by decoy receptors, secreted inhibitors (e.g., Follistatin), and alternative subunit incorporation. In research, recombinant Activin A is widely used to support stem cell proliferation and drive differentiation into endodermal and pancreatic lineages.
Applications
- Mesoderm induction in stem cells
- Endoderm and pancreatic differentiation
- Reproductive biology studies
- Tumor microenvironment modeling
- Neural development
Product Specifications
| Storage | -20°C |
| Storage Information | Avoid freeze/thaw cycles |
| Species | Human |
| Amino Acid Sequence | GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS |
| Molecular Weight | 13 kDa (Expected) |
| Class | Recombinant |
| Purity | > 95% by SDS-PAGE gel |
| Endotoxin Concentration | < 1 EU/µg |
| Biologically Active | Yes |
| Biological Activity | The biological activity is confirmed using a relevant signaling assay such as SMAD2/3 signaling assay. Each lot is tested to ensure consistent bioactivity. |
| Form | Lyophilized |
| Shipping Conditions | Ambient |
| Reconstitution | Reconstitute with sterile 10 mM Acetic Acid + 0.1% BSA |
