Product Description
HN Shell 700 utilizes the same advanced core-shell, multi-modal architecture as HN Shell 400 but is optimized for biomolecules larger than 700 kDa. The rigid outer shell integrates multiple interaction modes, delivering robust performance for extremely large biomolecule purification.
Applications
- Purification of extremely large biomolecules >700 kDa
- Excellent for viral vectors, mega-dalton complexes, and high-molecular-weight polymers
- Suitable for large-scale bioprocessing where high flow and low backpressure are required
- Ideal for workflows needing combined SEC + HIC/IEX behavior
Product Specifications
| Format | Liquid |
| Shipping | Gel Packs |
| Storage Solutions | 20% ethanol |
| Matrix | Highly crosslinked agarose core with functionalized polymeric shell |
| Ligand | Multi-modal (hydrophobic + ionic functional groups) |
| Particle Size | 80–120 µm |
| Dynamic Binding Capacity | Not applicable (size-exclusion resin) |
| pH Stability Operation | 3–12 |
| pH Stability Cleaning | 2–13 (short-term) |
| Cleaning/CIP | 0.1–0.5 M NaOH or 20% ethanol |
| Flow Rate | <600 cm/h |
| Chemical Stability | Compatible with NaOH ≤0.5 M, salts, mild detergents, 20% ethanol |
| Mode of Action | Size exclusion–dominant with secondary HIC/IEX effects |
| SBC | 2000 L |
| APC | 200,000 L |
| Application | Purification of biomolecules >700 kDa |
| Operating Pressure | <0.5 MPa |
